<110>    REGERON, INC.

<120>    COMPOSITION FOR IMPROVING SKIN CONDITIONS COMPRISING A FRAGMENT
         OF HUMAN HEAT SHOCK PROTEIN 90A AS AN ACTIVE INGREDIENT

<130>    FC14117WO

<150>    KR 10-2013-0094930
<151>    2013-08-09

<160>    33

<170>    KopatentIn 2.0

<210>    1
<211>    115
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence for HPf


<400>    1
Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu
  1               5                  10                  15 

Ser Glu Asp Lys Pro Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu
             20                  25                  30 

Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys
         35                  40                  45 

Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg
     50                  55                  60 

Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser
 65                  70                  75                  80 

Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His Phe Ser Val
                 85                  90                  95 

Glu Gly Gln Leu Glu Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala
            100                 105                 110 

Pro Phe Asp
        115


<210>    2
<211>    732
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Full amino acid sequence for HSP90a


<400>    2
Met Pro Glu Glu Thr Gln Thr Gln Asp Gln Pro Met Glu Glu Glu Glu
  1               5                  10                  15 

Val Glu Thr Phe Ala Phe Gln Ala Glu Ile Ala Gln Leu Met Ser Leu
             20                  25                  30 

Ile Ile Asn Thr Phe Tyr Ser Asn Lys Glu Ile Phe Leu Arg Glu Leu
         35                  40                  45 

Ile Ser Asn Ser Ser Asp Ala Leu Asp Lys Ile Arg Tyr Glu Ser Leu
     50                  55                  60 

Thr Asp Pro Ser Lys Leu Asp Ser Gly Lys Glu Leu His Ile Asn Leu
 65                  70                  75                  80 

Ile Pro Asn Lys Gln Asp Arg Thr Leu Thr Ile Val Asp Thr Gly Ile
                 85                  90                  95 

Gly Met Thr Lys Ala Asp Leu Ile Asn Asn Leu Gly Thr Ile Ala Lys
            100                 105                 110 

Ser Gly Thr Lys Ala Phe Met Glu Ala Leu Gln Ala Gly Ala Asp Ile
        115                 120                 125 

Ser Met Ile Gly Gln Phe Gly Val Gly Phe Tyr Ser Ala Tyr Leu Val
    130                 135                 140 

Ala Glu Lys Val Thr Val Ile Thr Lys His Asn Asp Asp Glu Gln Tyr
145                 150                 155                 160 

Ala Trp Glu Ser Ser Ala Gly Gly Ser Phe Thr Val Arg Thr Asp Thr
                165                 170                 175 

Gly Glu Pro Met Gly Arg Gly Thr Lys Val Ile Leu His Leu Lys Glu
            180                 185                 190 

Asp Gln Thr Glu Tyr Leu Glu Glu Arg Arg Ile Lys Glu Ile Val Lys
        195                 200                 205 

Lys His Ser Gln Phe Ile Gly Tyr Pro Ile Thr Leu Phe Val Glu Lys
    210                 215                 220 

Glu Arg Asp Lys Glu Val Ser Asp Asp Glu Ala Glu Glu Lys Glu Asp
225                 230                 235                 240 

Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu Ser Glu Asp Lys Pro
                245                 250                 255 

Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu Glu Lys Lys Asp Gly
            260                 265                 270 

Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys Tyr Ile Asp Gln Glu
        275                 280                 285 

Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg Asn Pro Asp Asp Ile
    290                 295                 300 

Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser Leu Thr Asn Asp Trp
305                 310                 315                 320 

Glu Asp His Leu Ala Val Lys His Phe Ser Val Glu Gly Gln Leu Glu
                325                 330                 335 

Phe Arg Ala Leu Leu Phe Val Pro Arg Arg Ala Pro Phe Asp Leu Phe
            340                 345                 350 

Glu Asn Arg Lys Lys Lys Asn Asn Ile Lys Leu Tyr Val Arg Arg Val
        355                 360                 365 

Phe Ile Met Asp Asn Cys Glu Glu Leu Ile Pro Glu Tyr Leu Asn Phe
    370                 375                 380 

Ile Arg Gly Val Val Asp Ser Glu Asp Leu Pro Leu Asn Ile Ser Arg
385                 390                 395                 400 

Glu Met Leu Gln Gln Ser Lys Ile Leu Lys Val Ile Arg Lys Asn Leu
                405                 410                 415 

Val Lys Lys Cys Leu Glu Leu Phe Thr Glu Leu Ala Glu Asp Lys Glu
            420                 425                 430 

Asn Tyr Lys Lys Phe Tyr Glu Gln Phe Ser Lys Asn Ile Lys Leu Gly
        435                 440                 445 

Ile His Glu Asp Ser Gln Asn Arg Lys Lys Leu Ser Glu Leu Leu Arg
    450                 455                 460 

Tyr Tyr Thr Ser Ala Ser Gly Asp Glu Met Val Ser Leu Lys Asp Tyr
465                 470                 475                 480 

Cys Thr Arg Met Lys Glu Asn Gln Lys His Ile Tyr Tyr Ile Thr Gly
                485                 490                 495 

Glu Thr Lys Asp Gln Val Ala Asn Ser Ala Phe Val Glu Arg Leu Arg
            500                 505                 510 

Lys His Gly Leu Glu Val Ile Tyr Met Ile Glu Pro Ile Asp Glu Tyr
        515                 520                 525 

Cys Val Gln Gln Leu Lys Glu Phe Glu Gly Lys Thr Leu Val Ser Val
    530                 535                 540 

Thr Lys Glu Gly Leu Glu Leu Pro Glu Asp Glu Glu Glu Lys Lys Lys
545                 550                 555                 560 

Gln Glu Glu Lys Lys Thr Lys Phe Glu Asn Leu Cys Lys Ile Met Lys
                565                 570                 575 

Asp Ile Leu Glu Lys Lys Val Glu Lys Val Val Val Ser Asn Arg Leu
            580                 585                 590 

Val Thr Ser Pro Cys Cys Ile Val Thr Ser Thr Tyr Gly Trp Thr Ala
        595                 600                 605 

Asn Met Glu Arg Ile Met Lys Ala Gln Ala Leu Arg Asp Asn Ser Thr
    610                 615                 620 

Met Gly Tyr Met Ala Ala Lys Lys His Leu Glu Ile Asn Pro Asp His
625                 630                 635                 640 

Ser Ile Ile Glu Thr Leu Arg Gln Lys Ala Glu Ala Asp Lys Asn Asp
                645                 650                 655 

Lys Ser Val Lys Asp Leu Val Ile Leu Leu Tyr Glu Thr Ala Leu Leu
            660                 665                 670 

Ser Ser Gly Phe Ser Leu Glu Asp Pro Gln Thr His Ala Asn Arg Ile
        675                 680                 685 

Tyr Arg Met Ile Lys Leu Gly Leu Gly Ile Asp Glu Asp Asp Pro Thr
    690                 695                 700 

Ala Asp Asp Thr Ser Ala Ala Val Thr Glu Glu Met Pro Pro Leu Glu
705                 710                 715                 720 

Gly Asp Asp Asp Thr Ser Arg Met Glu Glu Val Asp
                725                 730        


<210>    3
<211>    351
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for HPf


<400>    3
atggaagaaa aggaagacaa agaagaagaa aaagaaaaag aagagaaaga gtcggaagac         60

aaacctgaaa ttgaagatgt tggttctgat gaggaagaag aaaagaagga tggtgacaag        120

aagaagaaga agaagattaa ggaaaagtac atcgatcaag aagagctcaa caaaacaaag        180

cccatctgga ccagaaatcc cgacgatatt actaatgagg agtacggaga attctataag        240

agcttgacca atgactggga agatcacttg gcagtgaagc atttttcagt tgaaggacag        300

ttggaattca gagcccttct atttgtccca cgacgtgctc cttttgatta a                 351


<210>    4
<211>    37
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer HPf-up


<400>    4
gagacatatg gaagaaaagg aagacaaaga agaagaa                                  37


<210>    5
<211>    38
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer HPf-dn


<400>    5
tataggtacc ttaatcaaaa ggagcacgtc gtgggaca                                 38


<210>    6
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer HPf delta C1-dn


<400>    6
ggggtacctc attccaactg tccttcaact gaa                                      33


<210>    7
<211>    33
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer HPf delta C2-dn


<400>    7
ggggtacctc aatcttccca gtcattggtc aag                                      33


<210>    8
<211>    31
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer TRX-up


<400>    8
ttaattcata tgagcgataa aattattcac c                                        31


<210>    9
<211>    19
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer TRX-NGc-dn


<400>    9
accgtttttg aacagcagc                                                      19


<210>    10
<211>    48
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer TRX-TEVc-dn


<400>    10
ctggaagtac aggttttcgg atccattacc gtttttgaac agcagcag                      48


<210>    11
<211>    46
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer HPf-NGc-up


<400>    11
gctgctgttc aaaaacggtg aagaaaagga agacaaagaa gaagaa                        46


<210>    12
<211>    54
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer   HPf-TEVc-up


<400>    12
ggatccgaaa acctgtactt ccagggtgaa gaaaaggaag acaaagaaga agaa               54


<210>    13
<211>    31
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer   HGH-Nde-up


<400>    13
gagacatatg ttcccgacca tcccgctgtc t                                        31


<210>    14
<211>    58
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer   HGH-7His-dn


<400>    14
tttcggatcc agaaccatga tgatggtgat gatgatgacc gaagccacag ctgccctc           58


<210>    15
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer   HSP90(full)-up


<400>    15
gagacatatg cctgaggaaa cccagaccca gaccc                                    35


<210>    16
<211>    35
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer   HSP90(full)-dn


<400>    16
tataggtacc ttagtctact tcttccatgc gtgat                                    35


<210>    17
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for PCR primer   HSP90-5p(mid)


<400>    17
actggcggaa gataaagaga a                                                   21


<210>    18
<211>    255
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for TRX(NGc)


<400>    18
atgagcgata aaattattca cctgactgac gacagttttg acacggatgt actcaaagcg         60

gacggggcga tcctcgtcga tttctgggca gagtggtgcg gtccgtgcaa aatgatcgcc        120

ccgattctgg atgaaatcgc tgacgaatat cagggcaaac tgaccgttgc aaaactgaac        180

atcgatcaaa accctggcac tgcgccgaaa tatggcatcc gtggtatccc gactctgctg        240

ctgttcaaaa acggt                                                         255


<210>    19
<211>    282
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for TRX(TEVc)


<400>    19
atgagcgata aaattattca cctgactgac gacagttttg acacggatgt actcaaagcg         60

gacggggcga tcctcgtcga tttctgggca gagtggtgcg gtccgtgcaa aatgatcgcc        120

ccgattctgg atgaaatcgc tgacgaatat cagggcaaac tgaccgttgc aaaactgaac        180

atcgatcaaa accctggcac tgcgccgaaa tatggcatcc gtggtatccc gactctgctg        240

ctgttcaaaa acggtaatgg atccgaaaac ctgtacttcc ag                           282


<210>    20
<211>    101
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence for HPf delta C1


<400>    20
Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu
  1               5                  10                  15 

Ser Glu Asp Lys Pro Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu
             20                  25                  30 

Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys
         35                  40                  45 

Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg
     50                  55                  60 

Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser
 65                  70                  75                  80 

Leu Thr Asn Asp Trp Glu Asp His Leu Ala Val Lys His Phe Ser Val
                 85                  90                  95 

Glu Gly Gln Leu Glu
            100    


<210>    21
<211>    87
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    Amino acid sequence for HPf delta C2


<400>    21
Glu Glu Lys Glu Asp Lys Glu Glu Glu Lys Glu Lys Glu Glu Lys Glu
  1               5                  10                  15 

Ser Glu Asp Lys Pro Glu Ile Glu Asp Val Gly Ser Asp Glu Glu Glu
             20                  25                  30 

Glu Lys Lys Asp Gly Asp Lys Lys Lys Lys Lys Lys Ile Lys Glu Lys
         35                  40                  45 

Tyr Ile Asp Gln Glu Glu Leu Asn Lys Thr Lys Pro Ile Trp Thr Arg
     50                  55                  60 

Asn Pro Asp Asp Ile Thr Asn Glu Glu Tyr Gly Glu Phe Tyr Lys Ser
 65                  70                  75                  80 

Leu Thr Asn Asp Trp Glu Asp
                 85        


<210>    22
<211>    309
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for HPf delta C1


<400>    22
atggaagaaa aggaagacaa agaagaagaa aaagaaaaag aagagaaaga gtcggaagac         60

aaacctgaaa ttgaagatgt tggttctgat gaggaagaag aaaagaagga tggtgacaag        120

aagaagaaga agaagattaa ggaaaagtac atcgatcaag aagagctcaa caaaacaaag        180

cccatctgga ccagaaatcc cgacgatatt actaatgagg agtacggaga attctataag        240

agcttgacca atgactggga agatcacttg gcagtgaagc atttttcagt tgaaggacag        300

ttggaatga                                                                309


<210>    23
<211>    267
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for HPf delta C2


<400>    23
atggaagaaa aggaagacaa agaagaagaa aaagaaaaag aagagaaaga gtcggaagac         60

aaacctgaaa ttgaagatgt tggttctgat gaggaagaag aaaagaagga tggtgacaag        120

aagaagaaga agaagattaa ggaaaagtac atcgatcaag aagagctcaa caaaacaaag        180

cccatctgga ccagaaatcc cgacgatatt actaatgagg agtacggaga attctataag        240

agcttgacca atgactggga agattga                                            267


<210>    24
<211>    1527
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for MBP(TEVc)-HPf


<400>    24
atgaaaatcg aagaaggtaa actggtaatc tggattaacg gcgataaagg ctataacggt         60

ctcgctgaag tcggtaagaa attcgagaaa gataccggca ttaaagtcac cgttgagcat        120

ccggataaac tggaagagaa attcccgcag gttgcggcaa ctggcgatgg ccctgacatt        180

atcttctggg cacacgaccg ctttggtggc tacgctcaaa gcggcctgtt ggctgaaatc        240

accccggaca aagcgttcca ggacaagctg tatccgttta cctgggatgc cgtacgttac        300

aacggcaagc tgattgctta cccgatcgct gttgaagcgt taagcctgat ttataacaaa        360

gacctgctgc cgaacccacc gaaaacctgg gaagagatcc cggcgctgga taaagaactg        420

aaagcgaaag gtaagagcgc gctgatgttc aacctgcaag aaccgtactt cacctggccg        480

ctgattgctg ctgacggggg ttatgcgttc aagtatgaaa acggcaagta cgacattaaa        540

gacgtgggcg tggataacgc tggcgcgaaa gcgggtctga ccttcctggt tgacctgatt        600

aaaaacaaac acatgaatgc agacaccgat tacagcatcg cagaagctgc ctttaataaa        660

ggcgaaacag cgatgaccat caacggcccg tgggcatgga gcaacatcga caccagcaaa        720

gtgaattatg gtgtaacggt actgccgacc ttcaagggtc aaccgtccaa accgttcgtt        780

ggcgtgctga gcgcaggtat taacgccgcc agcccgaaca aagagctggc aaaagagttc        840

ctcgaaaatt atctgctgac tgatgatggt ctggaagcgg ttaataaaga caaaccgctg        900

ggtgccgtag cgctgaagag ctacgaagaa gagttggtga atgatccgcg tattgccgcc        960

actatggaaa acgcccagaa aggtgaaatc atgccgatca tcccgcagat gagcgttttg       1020

tggtatgccg tgcgtactgc ggtgatcaac gccgccagcg gtcgtcagac tgtcgatgaa       1080

gccctgaaag acgcgcagac tatgattaac ggcgatggtg ctggtctgga agtgctgttt       1140

cagggtccgg agctaggatc cgaaaacctg tacttccagg gtgaagaaaa ggaagacaaa       1200

gaagaagaaa aagaaaaaga agagaaagag tcggaagacc aacaagaaat tgaagatgtt       1260

ggttctgatg aggaagaaga aaagaaggat ggtaacaaga agaagaagaa gattaaggaa       1320

aagtacatcg atcaagaaga gctcaacaaa acaaagccca tctggaccag aaatcccgac       1380

gatattacta atgaggagta cggagaattc tataagagct tgaccaatga ctgggaagat       1440

cacttggcag tgaagcattt ttcagttgaa ggacagttgg aattcagagc ccttctattt       1500

gtcccacgac gtgctccttt tgattaa                                           1527


<210>    25
<211>    981
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for HGH(TEVc)-HPf


<400>    25
atgttcccga ccatcccgct gtctcgtctg tttgacaacg ctatgctccg cgcccatcgt         60

ctgcaccagc tggcctttga cacctaccag gagtttgaag aagcctatat cccaaaggaa        120

cagaagtatt cattcctgca gaacccccag acctccctct gtttctcaga gtctattccg        180

acaccctcca acagggagga aacacaacag aaatccaacc tagagctgct ccgcatctcc        240

ctgctgctca tccagtcgtg gctggagccc gtgcagttcc tcaggagtgt cttcgccaac        300

agcctggtgt acggcgcctc tgacagcaac gtctatgacc tcctaaagga cctagaggaa        360

ggcatccaaa cgctgatggg gaggctggaa gatggcagcc cccggactgg gcagatcttc        420

aagcagacct acagcaagtt cgacacaaac tcacacaacg atgacgcact actcaagaac        480

tacgggctgc tctactgctt caggaaggac atggacaagg tcgagacatt cctgcgcatc        540

gtgcagtgcc gctctgtgga gggcagctgt ggcttcggtc atcatcatca ccatcatcat        600

ggttctggat ccgaaaacct gtacttccag ggtgaagaaa aggaagacaa agaagaagaa        660

aaagaaaaag aagagaaaga gtcggaagac aaacctgaaa ttgaagatgt tggttctgat        720

gaggaagaag aaaagaagga tggtgacaag aagaagaaga agaagattaa ggaaaagtac        780

atcgatcaag aagagctcaa caaaacaaag cccatctgga ccagaaatcc cgacgatatt        840

actaatgagg agtacggaga attctataag agcttgacca atgactggga agatcacttg        900

gcagtgaagc atttttcagt tgaaggacag ttggaattca gagcccttct atttgtccca        960

cgacgtgctc cttttgatta a                                                  981


<210>    26
<211>    2199
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    Base sequence for HSP90a full CDS


<400>    26
atgcctgagg aaacccagac ccaagaccaa ccgatggagg aggaggaggt tgagacgttc         60

gcctttcagg cagaaattgc ccagttgatg tcattgatca tcaatacttt ctactcgaac        120

aaagagatct ttctgagaga gctcatttca aattcatcag atgcattgga caaaatccgg        180

tatgaaagct tgacagatcc cagtaaatta gactctggga aagagctgca tattaacctt        240

ataccgaaca aacaagatcg aactctcact attgtggata ctggaattgg aatgaccaag        300

gctgacttga tcaataacct tggtactatc gccaagtctg ggaccaaagc gttcatggaa        360

gctttgcagg ctggtgcaga tatctctatg attggccagt tcggtgttgg tttttattct        420

gcttatttgg ttgctgagaa agtaactgtg atcaccaaac ataacgatga tgagcagtac        480

gcttgggagt cctcagcagg gggatcattc acagtgagga cagacacagg tgaacctatg        540

ggtcgtggaa caaaagttat cctacacctg aaagaagacc aaactgagta cttggaggaa        600

cgaagaataa aggagattgt gaagaaacat tctcagttta ttggatatcc cattactctt        660

tttgtggaga aggaacgtga taaagaagta agcgatgatg aggctgaaga aaaggaagac        720

aaagaagaag aaaaagaaaa agaagagaaa gagtcggaag acaaacctga aattgaagat        780

gttggttctg atgaggaaga agaaaagaag gatggtgaca agaagaagaa gaagaagatt        840

aaggaaaagt acatcgatca agaagagctc aacaaaacaa agcccatctg gaccagaaat        900

cccgacgata ttactaatga ggagtacgga gaattctata agagcttgac caatgactgg        960

gaagatcact tggcagtgaa gcatttttca gttgaaggac agttggaatt cagagccctt       1020

ctatttgtcc cacgacgtgc tccttttgat ctgtttgaaa acagaaagaa aaagaacaac       1080

atcaaattgt atgtacgcag agttttcatc atggataact gtgaggagct aatccctgaa       1140

tatctgaact tcattagagg ggtggtagac tcggaggatc tccctctaaa catatcccgt       1200

gagatgttgc aacaaagcaa aattttgaaa gttatcagga agaatttggt caaaaaatgc       1260

ttagaactct ttactgaact ggcggaagat aaagagaact acaagaaatt ctatgagcag       1320

ttctctaaaa acataaagct tggaatacac gaagactctc aaaatcggaa gaagctttca       1380

gagctgttaa ggtactacac atctgcctct ggtgatgaga tggtttctct caaggactac       1440

tgcaccagaa tgaaggagaa ccagaaacat atctattata tcacaggtga gaccaaggac       1500

caggtagcta actcagcctt tgtggaacgt cttcggaaac atggcttaga agtgatctat       1560

atgattgagc ccattgatga gtactgtgtc caacagctga aggaatttga ggggaagact       1620

ttagtgtcag tcaccaaaga aggcctggaa cttccagagg atgaagaaga gaaaaagaag       1680

caggaagaga aaaaaacaaa gtttgagaac ctctgcaaaa tcatgaaaga catattggag       1740

aaaaaagttg aaaaggtggt tgtgtcaaac cgattggtga catctccatg ctgtattgtc       1800

acaagcacat atggctggac agcaaacatg gagagaatca tgaaagctca agccctaaga       1860

gacaactcaa caatgggtta catggcagca aagaaacacc tggagataaa ccctgaccat       1920

tccattattg agaccttaag gcaaaaggca gaggctgata agaacgacaa gtctgtgaag       1980

gatctggtca tcttgcttta tgaaactgcg ctcctgtctt ctggcttcag tctggaagat       2040

ccccagacac atgctaacag gatctacagg atgatcaaac ttggtctggg tattgatgaa       2100

gatgacccta ctgctgatga taccagtgct gctgtaactg aagaaatgcc accccttgaa       2160

ggagatgacg acacatcacg catggaagaa gtagactaa                              2199


<210>    27
<211>    7
<212>    PRT
<213>    Artificial Sequence

<220>
<223>    TEV protease recognition sequence


<400>    27
Glu Asn Leu Tyr Phe Gln Gly
  1               5        


<210>    28
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    base sequence for PCR sense primer of KRT10


<400>    28
ggtgggagtt atggaggcag                                                     20


<210>    29
<211>    23
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    base sequence for PCR antisense primer of KRT10


<400>    29
cgaactttgt ccaagtagga agc                                                 23


<210>    30
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    base sequence for PCR sense primer of TGM1


<400>    30
catcaagaat ggcctggtct                                                     20


<210>    31
<211>    20
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    base sequence for PCR antisense primer of TGM1


<400>    31
caatcttgaa gctgccatca                                                     20


<210>    32
<211>    22
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    base sequence for PCR sense primer of IVL


<400>    32
tcctccagtc aatacccatc ag                                                  22


<210>    33
<211>    21
<212>    DNA
<213>    Artificial Sequence

<220>
<223>    base sequence for PCR antisense primer of IVL


<400>    33
cagcagtcat gtgcttttcc t                                                   21
